*,*:before,*:after{box-sizing:border-box;margin:0;padding:0}:root{--bg: #141210;--bg2: #1C1916;--card: #221F1B;--card2: #1A1714;--text: #F5EFEA;--text-dim: #B7AFA7;--border: #2E2A25;--border2: #3A342E;--accent: #DAA99A;--accent-soft: #DAA99A;--success: #8C7B58;--cyan: #8D3437;--green: #8C7B58;--red: #C75C5F;--cyan-dim: #B07C7D;--black-chocolate: #1D190F;--mono: monospace;--sans: system-ui, -apple-system, BlinkMacSystemFont, sans-serif}body{background:var(--bg);color:var(--text);font-family:var(--sans);min-height:100vh}button{cursor:pointer;font-family:var(--sans);border:none;outline:none}input{font-family:var(--sans);outline:none}.app{min-height:100vh;background:var(--bg);background-image:radial-gradient(ellipse at 20% 20%,rgba(141,52,55,.08) 0%,transparent 50%),radial-gradient(ellipse at 80% 80%,rgba(140,123,88,.06) 0%,transparent 50%);padding:40px 16px 80px}.container{max-width:680px;margin:0 auto;display:flex;flex-direction:column;gap:24px}.header{text-align:center;padding:20px 0 8px}.header-logo{font-family:var(--mono);font-size:13px;letter-spacing:6px;color:var(--cyan);text-transform:uppercase;margin-bottom:16px;opacity:.8}.header h1{font-family:var(--mono);font-size:42px;font-weight:700;color:var(--text);letter-spacing:-1px;line-height:1;margin-bottom:10px}.header h1 span{color:var(--cyan)}.header p{font-size:14px;color:var(--text-dim)}.card{background:var(--card);border:1px solid var(--border);border-radius:16px;padding:28px;display:flex;flex-direction:column;gap:24px}.upload-zone{border:1.5px dashed var(--border2);border-radius:12px;padding:40px 24px;text-align:center;cursor:pointer;transition:all .2s;background:var(--bg2)}.upload-zone:hover{border-color:var(--cyan);background:#8d343714}.upload-zone.active{border-color:var(--cyan);background:#8d34371f}.upload-zone.has-file{border-color:var(--green);border-style:solid;background:#8c7b581a}.upload-icon{width:48px;height:48px;margin:0 auto 16px;border:1.5px solid var(--border2);border-radius:12px;display:flex;align-items:center;justify-content:center;background:var(--card2)}.upload-icon svg{width:22px;height:22px;stroke:var(--cyan);fill:none;stroke-width:1.5;stroke-linecap:round;stroke-linejoin:round}.upload-zone p{font-size:14px;color:var(--text-dim);line-height:1.6}.upload-zone .file-name{font-family:var(--mono);font-size:13px;color:var(--green);font-weight:700}.upload-zone .sub{font-size:12px;color:var(--text-dim);margin-top:4px}.upload-error{font-size:12px;color:var(--red);margin-top:8px}.section-label{font-size:11px;letter-spacing:2px;text-transform:uppercase;color:var(--text-dim);font-family:var(--mono);margin-bottom:12px}.drug-section{display:flex;flex-direction:column}.drug-chips{display:flex;flex-wrap:wrap;gap:8px;margin-bottom:12px}.drug-chip{padding:6px 14px;border-radius:100px;font-size:11px;font-family:var(--mono);font-weight:700;background:var(--accent-soft);color:var(--black-chocolate);border:1.5px solid var(--accent-soft);transition:.2s ease}.drug-chip:hover,.drug-chip.selected{background:var(--cyan);color:#fff;border-color:var(--cyan)}.drug-input{width:100%;background:var(--bg2);border:1.5px solid var(--border);border-radius:10px;padding:12px 16px;font-size:13px;color:var(--text);transition:border-color .2s}.drug-input::placeholder{color:var(--text-dim)}.drug-input:focus{border-color:var(--cyan)}.error-box{background:#ff174414;border:1px solid rgba(255,23,68,.3);border-radius:10px;padding:12px 16px;font-size:13px;color:var(--red)}.analyze-btn{width:100%;background:var(--cyan);color:#fff;font-family:var(--mono);font-size:13px;font-weight:700;letter-spacing:2px;text-transform:uppercase;border-radius:12px;padding:16px;transition:all .2s}.analyze-btn:hover:not(:disabled){background:var(--accent-soft)!important;color:var(--black-chocolate)!important;transform:translateY(-1px);box-shadow:0 8px 24px #8d34374d}.analyze-btn:disabled{background:var(--border2);color:var(--text-dim);cursor:not-allowed}.spinner-wrap{display:flex;flex-direction:column;align-items:center;justify-content:center;padding:48px;gap:16px}.spinner{width:40px;height:40px;border:2.5px solid var(--border2);border-top-color:var(--cyan);border-radius:50%;animation:spin .8s linear infinite}@keyframes spin{to{transform:rotate(360deg)}}.spinner-wrap p{font-family:var(--mono);font-size:12px;color:var(--text-dim);letter-spacing:2px}.result-card{background:var(--card);border:1px solid var(--border);border-radius:16px;overflow:hidden;animation:fadeUp .4s ease}@keyframes fadeUp{0%{opacity:0;transform:translateY(16px)}to{opacity:1;transform:translateY(0)}}.result-header{background:var(--card2);border-bottom:1px solid var(--border);padding:20px 28px;display:flex;justify-content:space-between;align-items:center}.result-header-left .label{font-family:var(--mono);font-size:10px;letter-spacing:2px;color:var(--text-dim);text-transform:uppercase;margin-bottom:4px}.result-header-left .value{font-family:var(--mono);font-size:16px;font-weight:700;color:var(--text)}.result-header-right{text-align:right}.result-header-right .label{font-family:var(--mono);font-size:10px;letter-spacing:2px;color:var(--text-dim);text-transform:uppercase;margin-bottom:4px}.result-header-right .drug-name{font-family:var(--mono);font-size:16px;font-weight:700;color:var(--cyan)}.result-body{padding:28px;display:flex;flex-direction:column;gap:20px}.risk-row{display:flex;justify-content:space-between;align-items:center}.risk-label-wrap .micro{font-size:10px;letter-spacing:2px;text-transform:uppercase;color:var(--text-dim);font-family:var(--mono);margin-bottom:8px}.risk-badge{display:inline-flex;align-items:center;padding:6px 16px;border-radius:100px;font-family:var(--mono);font-size:12px;font-weight:700;letter-spacing:1px;border:1.5px solid}.risk-badge.Safe{color:#8c7b58;border-color:#8c7b58;background:#8c7b5826}.risk-badge.Adjust{color:#daa99a;border-color:#daa99a;background:#daa99a26}.risk-badge.Toxic{color:#c75c5f;border-color:#c75c5f;background:#c75c5f26}.risk-badge.Ineffective{color:#b07c7d;border-color:#b07c7d;background:#b07c7d26}.risk-badge.Unknown{color:#8892a4;border-color:#8892a4;background:#8892a41a}.confidence-wrap{text-align:right}.confidence-wrap .micro{font-size:10px;letter-spacing:2px;text-transform:uppercase;color:var(--text-dim);font-family:var(--mono);margin-bottom:4px}.confidence-wrap .score{font-family:var(--mono);font-size:28px;font-weight:700;color:var(--text)}.gene-grid{background:var(--bg2);border:1px solid var(--border);border-radius:12px;padding:20px}.gene-grid .micro{font-size:10px;letter-spacing:2px;text-transform:uppercase;color:var(--text-dim);font-family:var(--mono);margin-bottom:16px}.gene-cols{display:grid;grid-template-columns:1fr 1fr 1fr;gap:16px;text-align:center}.gene-col .col-label{font-size:10px;letter-spacing:1.5px;text-transform:uppercase;color:var(--text-dim);font-family:var(--mono);margin-bottom:6px}.gene-col .col-value{font-family:var(--mono);font-size:15px;font-weight:700;color:var(--cyan)}.rec-box{background:#8d34370d;border:1px solid rgba(141,52,55,.2);border-radius:12px;padding:18px}.rec-box .rec-label{font-size:10px;letter-spacing:2px;text-transform:uppercase;color:var(--cyan-dim);font-family:var(--mono);margin-bottom:8px}.rec-box p{font-size:14px;color:var(--text);line-height:1.6}.explain-toggle{background:none;border:none;font-family:var(--mono);font-size:11px;letter-spacing:1.5px;text-transform:uppercase;color:var(--cyan);padding:0;transition:opacity .2s}.explain-toggle:hover{opacity:.7}.explain-box{background:var(--bg2);border:1px solid var(--border);border-radius:12px;padding:18px;margin-top:12px;font-size:14px;color:var(--text-dim);line-height:1.7;animation:fadeUp .2s ease}.disclaimer{font-size:11px;color:var(--text-dim);border-top:1px solid var(--border);padding-top:16px;line-height:1.5;font-style:italic}.action-btns{display:flex;gap:12px}.btn-copy{flex:1;background:var(--card2);border:1.5px solid var(--border2);color:var(--text);font-family:var(--mono);font-size:11px;font-weight:700;letter-spacing:1.5px;text-transform:uppercase;border-radius:10px;padding:12px;transition:all .2s}.btn-copy:hover{border-color:var(--accent);color:var(--accent)}.btn-download{flex:1;background:#8d34371a;border:1.5px solid var(--cyan);color:var(--cyan);font-family:var(--mono);font-size:11px;font-weight:700;letter-spacing:1.5px;text-transform:uppercase;border-radius:10px;padding:12px;transition:all .2s}.btn-download:hover{background:var(--cyan);color:#fff}gene{color:#b07cd4;font-weight:600}variant{color:#daa99a;font-weight:600}drug{color:#8c7b58;font-weight:600}diplotype{color:#7ca4d4;font-weight:600}cpic{color:var(--text-dim);font-weight:700;letter-spacing:1px}@keyframes slideIn{0%{transform:translateY(30px);opacity:0}to{transform:translateY(0);opacity:1}}.animate-slideIn{animation:slideIn .3s ease-out}@keyframes pulse-glow{0%,to{opacity:1;transform:scale(1)}50%{opacity:.85;transform:scale(1.03)}}@keyframes pulse-dot{0%{opacity:1;transform:scale(1)}50%{opacity:.3;transform:scale(1.8)}to{opacity:1;transform:scale(1)}}.heatmap-high{animation:heatmap-glow-high 1.5s ease-in-out infinite}.heatmap-critical{animation:heatmap-glow-critical .8s ease-in-out infinite}@keyframes heatmap-glow-high{0%{box-shadow:0 0 0 2px #8d3437}50%{box-shadow:0 0 20px 6px #8d343799}to{box-shadow:0 0 0 2px #8d3437}}@keyframes heatmap-glow-critical{0%{box-shadow:0 0 0 2px #c75c5f}50%{box-shadow:0 0 28px 8px #c75c5fb3}to{box-shadow:0 0 0 2px #c75c5f}}